MBL2 and myocardial infarction: This prompted the testing of complement-targeted therapies against IRI [10]: in rats, an analog of C3 convertase inhibitor protected against ischemia reperfusion (IR) complications; in mice, a Mannose-Binding Lectin (MBL) inhibitor prevented thrombogenesis, while monoclonal antibodies against MBL reduced complement deposition in vitro and post-myocardial infarction lesion in rats; recombinant soluble complement receptor 1 was beneficial in models of IR and in models of transplantation (lung and liver).