To more directly evaluate the involvement of PD-1/PD-1 ligand interactions in NK functional defect, we analyzed CD107a expression on PD-1neg and PD-1pos CD56dim NK cells from KS patients using redirected degranulation assays with anti-CD16 antibody bound to P815 or P815.PD-L1 cells (Figure 2C). Here, PDCD1 is linked to Kaposi's sarcoma.