We aim to identify the alteration of TRPM7 and related proteins involved in the EMT regulation using BCa tissues in vivo, and to observe its effects on EMT, cell migration/invasion, apoptosis and cell cycle in distinct BCa cell lines in vitro for a potential strategy of rescue experiment, as well as to analyze the influence of tumor growth using nude mice in vivo with deactivated TRPM7 and downregulated TRPM7 at transcriptional level. The gene discussed is TRPM7; the disease is neoplasm.