CLCA4 and neoplasm: Deregulated expression observed in common in both groups of (paired) tumor samples included increased expression of genes linked to liver metastatic sCRC, tumor development, growth (TACSTD2) [17] and invasiveness (FOXQ1, MMP7 and CLDN1) [18, 19], together with decreased expression of genes related to differentiation (CLCA4, CLCA1 and AQP8) [20, 21], apoptosis (CA1) [22], immunity (ZG16) [23], and protection (FCGBP and CA2) [24] of CRC cells.