Out of the MDM2 amplified SDCs identified in this study, two tumors showed a concomitant CDK4 amplification, one a grey-zone CDK4 amplification and one lacked an amplification of CDK4. This finding is in agreement with genomic data from a subset of liposarcomas, which frequently show a variable amplification of sequences of the chromosomal region 12q13-15. The gene discussed is CDK4; the disease is liposarcoma.