These significant associations persisted after further adjustment for clinical factors related to malnutrition-inflammation-atherosclerosis (MIA) syndrome (serum albumin, CRP, and hemoglobin) (Table 2; model 2) and mineral and bone disorders (MBD) (1,25-dihydroxyvitamin D3 and whole PTH) (Table 2; model 3). This evidence concerns the gene CRP and Marchiafava-Bignami disease.