In this regard, rs2244613, which is located in a CES1A1 intronic region, has been associated with decreased bioavailability of dabigatran, the activated metabolite of dabigatran exitelate, and reduced bleeding in dabigatran etxitelate-treated patients, and rs3815583 in the CES1A1 promoter, has been linked to appetite reduction among ADHD patients treated with methylphenidate e [24, 25]. Here, CES1 is linked to attention deficit-hyperactivity disorder.