RNF213 and multiminicore myopathy: Hitomi et al. first established MMD-specific iPSCs carrying RNF213 R4810K from skin fibroblasts and differentiated these cell lines into endothelial cells (ECs).[9] They reported that these cells featured impaired angiogenesis and concluded that the iPSCs-derived-ECs (iPSECs) can be regarded as an in vitro model of MMD because these ECs have a similar phenotype as those EPCs obtained from patients with MMD.