In myeloma cells, NOTCH signaling is thouhgt to be involved in BM homing, MM cell metastasis, and matrix invasion.11 In a patient with POEMS syndrome, stathmin-like 2 (STMN2), which encodes the microtubule regulatory protein stathmin, was found to be overexpressed. The gene discussed is STMN1; the disease is POEMS syndrome.