In addition, this reduction in MMP-2/9 correlated with the observed cognitive decline in all groups of mice (Figure 3B), reported in the T-water maze paradigm (Spearman r = −0.4254, *p = 0.0121; upper panel) and the NOR paradigm (Spearman r = 0.3510, *p = 0.0418; lower panel). The gene discussed is MMP2; the disease is Mental deterioration.