We found that unlike increased expression of merlin, which enhances the H2O2-induced activation of the Hippo pathway through increasing phosphorylation/activation of MST1/2 and Lats1 and phosphorylation/inactivation of YAP; increased expression of FRMD6 has little effect on the stress-induced activation of the Hippo components (Figure 5), suggesting that FRMD6 and merlin play a differential role in regulating the Hippo pathway in human glioblastoma. The gene discussed is LATS1; the disease is glioblastoma.