A Cox's proportional hazards regression analysis indicated that PON3 downregulation was an independent risk factor for both RFS (hazard ratio [HR] of 1.379, 95% confidence interval [CI] of 1.021-1.863, p = 0.036) and OS (HR of 1.687, 95% CI of 1.173-2.426, p = 0.005) in patients with HCC after curative hepatectomy (Table 2). This evidence concerns the gene PON3 and hepatocellular carcinoma.