A significant difference in tumor volume was observed three weeks post-injection (p = 0.008), and was increased throughout the study period until the experimental endpoint, at which the average tumor weight was approximately four-fold higher in tumors with PON3 knockdown (W = 937 mg) when compared with control tumors (W = 248 mg) (Figure 3A–3C). This evidence concerns the gene PON3 and neoplasm.