SMMC-7721, HCC-LM3, Huh7, and HepG2 cells were selected to generate stable cell lines with PON3 over-expression or knockdown (which we named SMMC-7721-PON3, HCC-LM3-PON3, Huh7-SH1 or -SH2, and HepG2-SH1 or -SH2), using recombinant lentiviruses containing full-length PON3 or shRNAs targeting PON3. This evidence concerns the gene PON3 and hepatocellular carcinoma.