Noticeably, we found strong negative correlations between PON3 expression and many progressive clinical features, including poor differentiation (p < 0.001), tumor size ≥ 5 cm (p = 0.008), absence of encapsulation (p = 0.026), serum AFP levels of ≥ 20 μg/L (p < 0.001), and early recurrence (p = 0.010) (Table 1). The gene discussed is AFP; the disease is neoplasm.