JAG2 and retinoblastoma: To determine which downstream signaling pathways might be involved in the suppression of growth and clonogenicity upon downregulation of Jag2 ligand in the retinoblastoma cells, microarray analysis was performed on mRNA extracted from WERI Rb1 and Y79 cells transduced with two different Jag2 shRNAs (#1, #2) as compared to shRNA controls and parental lines.