Consistent with this hypothesis, recent data revealed several mechanisms of regulation of TUSC2: different miRNAs (named miR-98, -93 -197 and -378) have been identified as negative regulators of TUSC2 [50, 51]; methylation of TUSC2 was identified in head and neck tumors [52]; myristoylation of the TUSC2 protein has been reported in lung cancers [53]; and two TUSC2 pseudogenes were identified as regulators of TUSC2 activities [54]. This evidence concerns the gene TUSC2 and head and neck neoplasm.