Suppression of CRC proliferation with RTK inhibitors was significantly higher in the control group (percentage reduction in proliferation with the treatment compared to the untreated cells; mean +/− SD: 54.17 +/−18.17%) compared to c-Cbl silenced cells (24.86 +/−11.39, p < 0.0001) (Figure 5G). Here, CBL is linked to colorectal carcinoma.