CBL and atypical chronic myeloid leukemia, BCR-ABL1 negative: c-Cbl missense or small deletions predominantly in c-Cbl's RING finger and linker region contribute to myeloproliferative disorders, including atypical chronic myeloid leukemia, myelofibrosis juvenile myelomonocytic leukemia, myelodysplastic syndrome, etc. [18–20].