A significant negative correlation of average normalized c-Cbl and nuclear β-catenin was observed in 83 CRC patients (p < 0.0001, Spearman correlation −0.64) (Figure 1C), and also in 435 pairs of individual images (p < 0.001, Spearman correlation coefficient - 0.68) (Supplementary Figure 1D). The gene discussed is CBL; the disease is colorectal carcinoma.