The risk of having rheumatic disease for females, with age more than 18 years, and with positive RF, anti-CCP, RF in association with anti-CCP, ANA, anti-dsDNA, anti-ENA, especially anti-uRNP, is more than male, age less than or equal to 18 years, and in association with negative markers, respectively. The gene discussed is ENAH; the disease is rheumatic disorder.