For instance, BMP-2 and BMP-7 function as potent tumor suppressors in gastric carcinoma, renal cell carcinoma, lung and colorectal cancer, and osteosarcoma, in which BMPs suppress tumor growth by reducing the gene expression of tumorigenic factors and inducing the differentiation of cancer stem cells (CSCs) [30-33]. Here, BMP7 is linked to osteosarcoma.