IGF-IR impairs JNK, SHC, MAPK in B-ALL Y1250F/Y1251F mutant cells; IGF-I stimulation induced phosphorylation of AKT in the mutant cells, suggesting the Y1250F/Y1251F mutations can only hinder JNK, SHC, and MAPK pathwaysIGF-IR inhibition decreases PI3K/AKT, MAPK pathways while decreasing BCL-2 and BCL-XLand increases cleaved caspase 3 and PARP. The gene discussed is BCL2; the disease is precursor B-cell acute lymphoblastic leukemia.