IGF1 and paracoccidioidomycosis: In further support of an important role of IGF-I/IGF-IR signaling in PCM, studies from different labs showed that IGF-IR and IGF-I are highly expressed in PCM, and that the IGF-I/IGF-IR signaling axis, at least partially through an autocrine cascade, contributes significantly to the survival and progression of PCM [54, 132].