The best performing algorithm to compute the Immunoscore has been defined in the large international SITC -led retrospective validation study [1, 2] conducted on more than 3800 St I-III colon cancer patients, Briefly, for each marker (CD3 & CD8) and each zone (CT & IM), densities distributions have been established on the study training set; for each parameter of a tested sample (CD3, CD8, CT, IM), a percentile is derived from these distributions. This evidence concerns the gene CD8A and colonic neoplasm.