Preclinical data suggests that RT can promote memory T-cell formation through release of cytokines and upregulation of MHC-1, [47, 48] providing rationale for a phase 1 study that combined 1-3 fractions of RT (20 Gy per fraction) with high dose IL-2 for patients with metastatic RCC and melanoma. The gene discussed is IL2; the disease is melanoma.