Despite the lower blood glucose concentrations before lunch with LM25 and the general concern that premixed insulin may increase the risk of hypoglycemia [20], we found that, while the rates of hypoglycemia in the Latin American subpopulation were numerically higher than those observed in the trial-level population [12], both the incidence and rate of hypoglycemia during the study were similar between the 2 study groups. The gene discussed is INS; the disease is Hypoglycemia.