To our knowledge, this is the first report to disclose results from a Latin American subpopulation in a study comparing a twice-daily premixed insulin regimen with a once-daily basal insulin plus once-daily prandial insulin regimen in patients with T2DM not adequately controlled on insulin glargine with metformin and/or pioglitazone. The gene discussed is INS; the disease is type 2 diabetes mellitus.