ACE and Hypoglycemia: There was no significant association between 5-year change in any of the three cognitive tests and the following baseline risk variables: body mass index, waist–hip ratio, gender, smoking, education, serum creatinine, microalbuminuria, plasma total cholesterol, LDL cholesterol, HDL cholesterol or triglyceride concentration, any baseline hypoglycemia, (any or severe) post-baseline hypoglycemia, baseline use of insulin, TZD, ACE inhibitor, ARBs, or fish oil medication.