IGHE and chronic obstructive pulmonary disease: The levels of B-lymphocytes (CD19+) in patients with asthma were increased in comparison with control group (p1-3 = 0.000010) and COPD patients (p2-3 = 0.000001), indicating the activation of humoral immune system, which is supported by high levels of IgE (p1-3 = 0.000001, p2-3 = 0.000010) and is specific for allergic inflammation.