The allergic sensitization in 66.7% of patients, asthma episodes before 40 years in 50% of patients with ACOS syndrome, high levels of eicosanoids in serum, low production of Th1-type cytokines (IFN-γ), and high synthesis of opposition IL-4, together with the increased production of IgE, indicate an active inclusion of the mechanisms of switching to Th2-helpers in patients with ACOS, requiring further studies. Here, IGHE is linked to asthma.