Thus, several investigations have demonstrated that selective 5-HT2 blockade displays protective effects in both T1D and type 2 diabetes17, 18, 19, 20, 21; in this study, we aim to determine the impact of modulating the serotonergic system, by the selective blockade of the 5-HT2 receptors (sarpogrelate), on the development of hypertension, cardiac and renal hypertrophy, oxidative stress and endothelial dysfunction in an experimental model of T1D. Here, HTR2A is linked to endothelial dysfunction.