Although the beneficial effect of sarpogrelate treatment on the cardiovascular system has been well documented, its antihypertensive effect has not been reported elsewhere17, 18, 32; nevertheless, our findings show that blocking 5-HT2 receptors during 14 days with sarpogrelate exerts a protective effect on the onset of hypertension in T1D. This evidence concerns the gene HTR2A and hypertensive disorder.