Thus, several investigations have demonstrated that selective 5-HT2 blockade displays protective effects in both T1D and type 2 diabetes17, 18, 19, 20, 21; in this study, we aim to determine the impact of modulating the serotonergic system, by the selective blockade of the 5-HT2 receptors (sarpogrelate), on the development of hypertension, cardiac and renal hypertrophy, oxidative stress and endothelial dysfunction in an experimental model of T1D. This evidence concerns the gene HTR2A and type 1 diabetes mellitus.