In particular, those related to lymphocytic lobulitis (LLO), a characteristic pattern of inflammation frequently observed in non-neoplastic lobular structures adjacent to hereditary breast cancer, as well as in prophylactically removed breast tissue from patients without and with cancer-predisposing germ line aberrations BRCA1/227, 31, 32, 33, 34, 35. The gene discussed is BRCA1; the disease is Hereditary breast cancer.