TP53 and clear cell adenocarcinoma: In clear cell carcinomas without TP53 mutations, high MDM2 expression was significantly associated with poor progression-free survival (PFS) (P = 0.0002 by log-rank test, Figure 1C), as was advanced stage (P = 0.0002 by log-rank test, Supplementary Figure 1C), but not age (Supplementary Figure 1D).