MDM2 and cancer: In addition, multivariate analysis indicated that high MDM2 expression was a poor prognostic factor for PFS (HR = 5.61, 95% CI = 2.11-16.62, P = 0.0005) and OS (HR = 6.14, 95% CI = 1.85-24.32, P = 0.0028, independent of age and cancer stage (Table 1).