BRCA2 and breast carcinoma: Furthermore, we also observed statistically significant association of tumor BRCA1 and BRCA2 mutations with OS (BRCA1: adjusted HR 1.50, 95% CI 1.16 to 1.93, P = 0.079; BRCA2:adjusted HR 1.50, 95% CI 1.03 to 2.19, P = 0.079), but not with BCSS or EFS in breast cancer patients (Supplementary Table S1) using trim and filled method to test the internal validity, which was consistent with the primary analyses.