VDAC1 and metastatic malignant neoplasm in the lymph nodes: By the factors analyzed, the results revealed that the expression of VDAC1 (HR = 1.544, 95%CI:0.794–3.0,P = 0.021) and lymph node metastasis (HR = 5.375, 95% CI:1.225–23.584,P = 0.026) both were independent prognostic factors (Fig. 5A,D).