Drugs responsible for this hepatic lesion can also induce a mixed form of fat accumulation with macrovacuolar steatosis and microvesicular steatosis occurring in anatomically adjacent hepatocytes, the formation of which may depend on proteins such as perilipin and adipophilin associated with lipids and possible presence of free fatty acids (Fromenty and Pessayre 1995). This evidence concerns the gene PLIN1 and steatosis.