While for classical scrapie polymorphic variants along the PrPC have been associated to modulate the susceptibility to the disease, for atypical scrapie only few have been reported—A/V136, F/L141, R/H154 and Q/R171 [4, 19]— that, interestingly, are all located within β1–α1 and β2–α2 loops. The gene discussed is PRNP; the disease is scrapie.