Only 1 study of blood with 72 CRC and 40 benign mucosal lesions showed that SFRP1 methylation had a higher OR in blood samples from patients with CRC than in blood samples from patients with benign mucosal lesions (OR = 11.25, P < 0.001) (Fig. 3). Here, SFRP1 is linked to colorectal carcinoma.