These superantigens, in particular Staphylococcus aureus enterotoxins (SAEs), are strongly associated with chronic rhinosinusitis with nasal polyps (CRSwNP), particularly in the subpopulation of patients with aspirin-exacerbated respiratory disease (AERD), as well as those with allergic rhinitis, asthma, and atopic dermatitis.2, 3, 4, 5 SAEs are a family of structurally related proteins comprising different serological types, such as staphylococcal enterotoxin (SE) A, SEB, SEC, SED, and SEE (up to SEU) and toxic shock syndrome toxin 1 (TSST-1).6 Here, SETBP1 is linked to atopic eczema.