IGHE and allergic disease: In previous studies it has been demonstrated that certain antibodies against a specific allergen are more frequently observed than others in atopic patients; such allergens, that is, Der p 1 and Der p 2 in patients with house dust mite allergy, are said to be dominant allergens.61, 62 These allergens usually have multiple epitopes, allowing more extensive cross-linking of the IgE-FcεRI complexes on effector cells.