GGCT and Familial prostate cancer: As shown in Fig. 2, knockdown of GGCT induced cellular senescence, as detected by SA-β-Gal staining, in MCF7 and MDA-MB-231 cells, as well as other cancer cell lines, including PC3 and LNCaP prostate cancer cells, HeLa cervical cancer cells, and A172 glioblastoma cells.