Zhou detected that A2aR was down-regulated in severe IPF patients [33], but in our study, an increased A2aR expression was determined in lung tissue in BLM-treated WT mice, which may be a provisional compensatory increase and related to the course of IPF, we will clarify the detailed change of A2aR in the future. This evidence concerns the gene ADORA2A and idiopathic pulmonary fibrosis.