ARSB and hyperinsulinemic hypoglycemia, familial, 4: We used a similar approach in animal models of mucopolysaccharidosis type VI (MPS VI; OMIM #253200), a rare LSD caused by deficiency of arylsulfatase B (ARSB), which leads to the lysosomal accumulation and urinary excretion of elevated amounts of the glycosaminoglycan (GAG) dermatan sulfate.28 We demonstrated that a single systemic administration of AAV2/8 encoding ARSB is able to convert the liver into a stable and long-term source of systemic ARSB.