Punica granatum also has been shown to inhibit cyclooxygenase, lipooxygenase [51] and IL-1β, modulate matrix metallo-proteinases in osteoarthritis, prevent collagen degradation [52], inhibit the p38-mitogen-activated protein kinase pathway and nuclear factor kappa (NF-kB) light-chain-enhancer in B cells [53, 54], and decrease malondialdehyde, TNF-α, IL-1β and IL-6 [55, 56]. Here, IL1B is linked to osteoarthritis.