Comparing FLT3+- and FLT3−-ETP-ALL, we found lower GATA3 expression (0.5 vs. 7.0, p < 0.0001) and higher GATA3 methylation as detected by pyrosequencing (51 vs. 8 %, p < 0.0001) in FLT3+-ETP-ALL. Here, GATA3 is linked to acute lymphoblastic leukemia.