We used PER-117 as a model for GATA3low ETP-ALL with high GATA3 DNA methylation (mean DNA methylation 92 % \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$ \pm $$\end{document}± 1 %), low GATA3 mRNA expression (relative expression to Jurkat 0.002), and an ETP-like immunophenotype and GEP (Additional file 3: Figure S2). The gene discussed is GATA3; the disease is acute lymphoblastic leukemia.