DNMT3A and acute lymphoblastic leukemia: We and others have characterized the mutational landscape of ETP-ALL with alterations in genes involved in cytokine and RAS signaling (e.g., NRAS, KRAS, FLT3, and JAK1), epigenetic regulation (e.g., EZH2, DNMT3A, and SUZ12), and hematopoietic development (e.g., ETV6, RUNX1, and IKZF1) [19, 20].