To explore the regulation of GATA3 expression, we investigated global DNA methylation on the Illumina HumanMethylation 450 k platform in 12 ETP-ALL samples (Fig. 2), which were selected according to GATA3 mRNA expression (GATA3low vs. GATA3high) and mutational status of DNMT3A. The genomic locus of GATA3 (NC_000010.10) was represented by 72 CpG sites. The gene discussed is DNMT3A; the disease is acute lymphoblastic leukemia.