In this study, we compared psoriasis genetic risk score (GRS) between patients with psoriasis and healthy controls by analysis of five known susceptibility markers: HLA-C*06, LCE3C_LCE3B-del and three single nucleotide polymorphisms (SNPs): rs26653 located within the ERAP1 gene, rs17695937 linked to the ZAP70 gene and rs17589 located within the CSTA gene. This evidence concerns the gene HLA-C and psoriasis.