The odds ratios revealed that HLA-C*06, rs26653 G, LCE3C_LCE3B-del, rs17589 T and rs17695937 A alleles predispose to psoriasis, but the results were statistically significant only in case of HLA-C*06 and rs26653 G. The lack of significant association of LCE3C_LCE3B-del, rs17589 and rs17695937 alleles with psoriasis may result from the fact that the studied population was relatively small when compared to other investigations. The gene discussed is HLA-C; the disease is psoriasis.