CORIN and obesity due to melanocortin 4 receptor deficiency: Human corin, a type II transmembrane serine protease, is highly expressed by cardiomyocytes.[7, 8] It plays a key role in the regulation of blood volume, blood pressure and cardiac function through activating natriuretic peptides.[9, 10] Corin is shed from the myocyte cell surface, enters the circulation, and is easily measurable.[11] Soluble corin in the circulation has been studied in some disease states, such as heart failure [12], hypertension [13], obesity [14], and pregnant hypertension [15], all of which are associated with stroke prognosis.