ITGAM and atherosclerosis: They play an important role in atherosclerosis, where fibrinogen accumulation is detected under the endothelial layer, furthermore, monocytes were shown to upregulate CD11b and CD11c expression under hypertriglyceridemic conditions [37, 38] or in rheumatoid arthritis, where elevated CD11b levels and enhanced adhesive properties of monocytes were already shown [39].