TP53 and acute myeloid leukemia: We decided for this approach since no C-allele was detectable by Sanger sequencing of the bulk specimen and since, as indicated by FISH and CNV array, the AML harbored one or more clones with loss of a chromosome 17p allele (including TP53; S4 Fig), and chromosomal loss of TP53 in cancers preferentially affects the C-allele of rs1042522 [25].