U-2 OS harbors mutations in the SLC34A2 (ENST00000382051: c.1538G>T; p.R513L) and TET2 genes (ENST00000380013: c.1394C>T; p.P465L) [17], both of which are of functional relevance in cancers [19–21]. The gene discussed is TET2; the disease is cancer.