In our previous work, we demonstrated that FHC-silencing is accompanied, in K562 cells, by an increased expression of a repertoire of miRNAs and by a reduced proliferation rate [20]; in human metastatic melanoma cells FHC-knockdown determines, in vitro, decreased cell growth and adhesion activity and, in vivo, a consistent reduction of tumour growth [21]. The gene discussed is FTH1; the disease is metastatic melanoma.