In this work, we explored immune-associated substances previously reported to be altered in CSF or plasma in HD, namely proinflammatory cytokines–TNF-α, IL-1β, IL-6 and IL-8 –and microglial markers–YKL-40 and chitotriosidase–in the CSF of well-characterised patients, to determine what markers are capable of predicting clinical severity in HD. This evidence concerns the gene TNF and Huntington disease.