Numerous post-mortem and in vivo studies have shown that complement activation[5], microglial activation[6],[7] and concentrations of pro-inflammatory and immunomodulatory cytokines IL-1β, IL-6, IL-8, IL-10, CCl2 and TNF-α[4, 8] are increased in peripheral blood in HD patients compared with controls. This evidence concerns the gene TNF and Huntington disease.