In this present meta-analysis, we demonstrated that the overexpression of vimentin predicted a poor overall survival of NSCLC in the univariate analysis and up-regulated vimentin expression was associated with several clinicopathological factors, including histology of squamous cell carcinoma, smoking, poor differentiation, advanced TNM stages, vascular invasion, lymph node metastasis and recurrence in NSCLC. The gene discussed is VIM; the disease is non-small cell lung carcinoma.