He et al reported that vimentin overexpression and the EMT were induced by metadherin (MTDH) via the Wnt/β-catenin pathway in lung cancer, which is essential to the invasion and metastasis of cancer progression and may support the results of this meta-analysis that vimentin was associated with vascular invasion and lymph node metastasis in NSCLC[52]. Here, VIM is linked to metastatic malignant neoplasm in the lymph nodes.