The DM5+/wt/ Prkca-/-/Prkcb-/- and a control group of DM5+/wt/ Prkca+/+/Prkcb+/+ mice did not show any evidence of myotonia by EMG) or cardiac conduction abnormalities (by ECG) prior to induction of RNA toxicity. This evidence concerns the gene PRKCB and Myotonia.