These cells depend on a homologous recombination (HR) DNA-repair mechanism to maintain telomere length [4,5] and are characterized by the presence of: heterogeneous telomere lengths; the observation of ALT-associated promyelocytic leukemia bodies (APBs) that differ from common promyelocytic leukemia (PML) bodies found in other cell types by the inclusion of telomeric DNA and numerous specific recombination factors [6]; and telomere recombination with the presence of extrachromosomal (linear and circular) telomeric repeats (ECTRs) [7]. This evidence concerns the gene PML and acute promyelocytic leukemia.