Metastasis and invasiveness also emerge during this stage, via the angiogenesis process, with the growth of new blood capillaries in the tumor, which is enhanced by the secretion of specific growth factors and growth factor receptors, such as platelet-derived growth factor (PDGF), PDGF receptor (PDGFR), vascular endothelial growth factor (VEGF), and VEGF receptor (VEGFR), leading to overgrowth and spread of the tumor [26]. Here, KDR is linked to neoplasm.