Resveratrol leads to autophagy induction via the up-regulation of p62/sequestome-1 (SQSTM1), and AMPK/mTOR-mediated, by JNK in imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cells (CML) K562 [121]. The gene discussed is SQSTM1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.