Polyphenols present preventive effects against tumor initiation via numerous mechanisms, such as prevention of the formation of genotoxic molecules and blocking the activity of the mutagens-transforming enzymes [19,20]; regulation of heme-containing phase I enzymes, such as cytochrome P450s (CYPs) [21,22]; regulation of carcinogen-detoxifying phase II enzymes, such as NADPH-quinone oxidoreductase-1 (NQO1), quinone reductase (QR), glutathione S-transferase (GST), and uridine diphospho (UDP) glucuronosyl transferase (UGT) [23,24]; and prevention of the formation of DNA adducts [25]. Here, NQO1 is linked to neoplasm.