ERVW-1 and viral infectious disease: There are still many questions left to be answered, including the identities of the dislocons that each envelope glycoprotein is targeted to, the motifs or patterns that allow α1,2-mannosidases to differentiate between native and misfolded glycoproteins, why some viral proteins are disproportionately targeted (HCMV gH), and the roles that the UPR and ERAD play in vivo during viral infections.