Similarly, hybrids derived from breast epithelial cells (M13SV1-EGFP-Neo) and breast cancer cells (MDA-MB-435-Hyg) showed altered sensitivity to the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 as a consequence of differential RAF-AKT (Rapidly Accelerated Fibrosarcoma-Akt) crosstalk among hybrids [31]. Here, AKT1 is linked to breast cancer.