LPS, the active component of endotoxins, interacts with LPS-binding protein and the CD14 receptor, activating TLRs and, consequently, the inflammatory cascade that involves stress-activated protein kinases, JNK, p38, interferon regulatory factor-3 (IRF-3) and NF-κB, pathways implicated in insulin resistance and triglycerides synthesis [252,325]. This evidence concerns the gene IRF3 and Insulin resistance.